Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11010852 | Pharmacological Reports | 2018 | 34 Pages |
Abstract
Neurodegenerative diseases are currently a major challenge in elderly care due to demographic changes and dramatic increases in the aging population worldwide. This review is focused on the most promising research discovering ways to attenuate neural loss or enhance neuroprotection and unraveling the basis of neurodegeneration using transgenic mouse models. With the recent introduction of the powerful and relatively simple gene-editing tool CRISPR-Cas9, we have entered a new era in genetic engineering that will certainly lead to a variety of new transgenic models in the near future. The aim of this review is to note the most interesting avenues addressing unmet needs in neurodegenerative disease research that could provide promising targets for both the development of new models and the study of existing ones.
Keywords
phosphatase and tensin homolog on chromosome 10TIF-IAFTDAPPLRRK2DATMPTPVTASCAMSNsVMATmTORAβMAPTSNCACRISPRTFAMhttlocus ceruleus1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinel-DOPAl-dihydroxyphenylalanineROSα-synucleinspinocerebellar ataxiaApoeapolipoprotein EDopamine transporterBeta-amyloidFADLewy bodiesclustered regularly interspaced short palindromic repeatsAlzheimer’s diseasefamilial Alzheimer’s diseaseHuntington’s diseaseNeurodegenerative diseasesParkinson’s diseasesubstantia nigraNeurodegenerationleucine-rich repeat kinase 2Vesicular monoamine transportertransgenic animalsmitochondrial transcription factor Afrontotemporal dementiaGenetic modelsMiceRatsventral tegmental areaknockoutnoradrenalinemedium spiny neuronsHuntingtinmammalian target of rapamycinPresenilinmicrotubule-associated protein tauamyloid precursor proteinPtenReactive oxygen speciesEstrogen receptor
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Authors
Grzegorz Kreiner,