Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors

Article ID	Journal	Published Year	Pages	File Type
11011566	Bioorganic & Medicinal Chemistry Letters	2018	21 Pages	PDF

Keywords

SGLT1 inhibitor Bioisostere Diabetes Glucose transporter SGLT2 inhibitor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors

Authors

Guozhang Xu, Michael D. Gaul, Gee-Hong Kuo, Fuyong Du, June Zhi Xu, Nathaniel Wallace, Simon Hinke, Thomas Kirchner, Jose Silva, Norman D. Huebert, Seunghun Lee, William Murray, Yin Liang, Keith Demarest,