Metal complexes of anthranilic acid derivatives: A new class of non-competitive α-glucosidase inhibitors

Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I) complexes (9–16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I) (9) was the most potent (IC50 = 3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report.

Graphical abstractMetal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I) complexes (9–16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I) (9) was the most potent (IC50 = 3.21 nmol/L).Figure optionsDownload full-size imageDownload as PowerPoint slide