| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1301647 | Inorganic Chemistry Communications | 2014 | 6 Pages |
•A series of Ag–NHC complexes are prepared.•All complexes are linearly coordinated by two NHC ligands.•Imidazolium salts and complexes are evaluated for anticancer activity.•Complexes showed promising anticancer potential compared with salts.
Reactions of symmetrically and non-symmetrically substituted nitrile-functionalized imidazolium salts (1–3) with silver(I) oxide in methanol at room temperature afforded complexes (4–6) of the type [NHC-Ag-NHC]PF6, (NHC: imidazol-2-ylidene). All reported compounds have been characterized by spectral (1H, 13C NMR and FTIR) and elemental analysis. The structure of bis-imidazolium salt 3 and silver complex 4 was unambiguously elucidated by the single-crystal X-ray diffraction method. The effect of substitutions on the anticancer activity of compounds 1–6 has been investigated by in vitro cytotoxicity studies against human colorectal (HCT 116) cancer cell line, using the MTT assay method. All three silver complexes (4–6) displayed promising anticancer activity with IC50 values of 6.0 ± 0.2, 14.0 ± 0.6 and 4.0 ± 0.2 μM, while imidazolium salts, 1–3, showed least (> 200 μM) to moderate (20.3 ± 0.2 and 95.0 ± 2 μM) anticancer potential, respectively. Bis-imidazolium salt 3 and binuclear complex 6 displayed good activity against human breast (MCF-7) cancer line with IC50 values of 82.4 ± 2.5 and 0.9 ± 0.4 μM, respectively.
Graphical abstractThree N,N′-disubstituted substituted nitrile-functionalized imidazolium salts and corresponding silver(I)–NHC complexes are prepared. All compounds were tested for anticancer activity showing that all three silver complexes are promising anticancer agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
