Efficient palladium-catalyzed Suzuki cross-coupling reaction with β-ketoamine ligands

A series of β-ketoamine ligands with different steric and electronic substituents on the backbone and with aniline moieties have been synthesized and characterized. In the presence of PdCl2, catalytic studies indicated that they are effective ligands for Suzuki cross-coupling of various aryl bromides with phenylboronic acid, under aerobic conditions.

Graphical AbstractA series of β-ketoamine ligands were synthesized and employed in Suzuki cross-coupling reaction under aerobic conditions. The catalytic reaction revealed that the ligand with bulky and electron-donating group was most efficient, enabling a wide variety of aryl bromides to be coupled with phenylboronic acid in high yield.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights► β-ketoamine ligands applied in Suzuki cross-coupling reaction were prepared. ► The bulky and electron-donating groups on ligands are benefit for the reaction. ► Reaction conditions of the cross-coupling were optimized.