Study of the first antibacterial agent pipemidic acid modifying Keggin polyoxometalate

A new compound based on polyoxometalates (POMs) and the quinolone antibacterial pipemidic acid (HPPA), {[Co(PPA)2]H2[ SiW12O40]}·HPPA·3H2O (1), has been prepared and characterized by elemental analyses, IR and singe crystal X-ray diffraction. The title compound represents the first example of POMs modified by the quinolone antibacterial HPPA, in which the POMs are modified by [Co(HPPA)2] subunits. Its antitumor activity on MCF-7 cells was investigated by the. The results show that the title compound exhibits higher antitumor activity than its parent, which indicates that introduction of M-PPA into the POM surface can increase their antitumor activity and make the compounds to penetrate into the cells easily.

Graphical abstractThe first compound based on POMs and the quinolone antibacterial pipemidic acid was prepared. And the results of antitumor activity indicate that introduction of M-PPA into the polyoxoanion surface can increase their antitumor activity and make the compounds to penetrate into the cells easily.Figure optionsDownload full-size imageDownload as PowerPoint slide