An unexpected oxovanadium(IV) complex with in situ generated lactone ligand: Synthesis, crystal structure and DNA-binding property

A novel unexpected oxovanadium(IV) complex, [VO(L)(Phen)] (H2L = 2-((2-hydroxynaphthalen-1-yl)-methyleneamino)-5-oxotetrahydrofuran-2-carboxylic acid, Phen = 1, 10-phenanthroline) (1), in which the L2– is an unexpected in situ generated lactone Schiff base ligand from the precursor of K2HL1 (K2HL1 = potassium 2-(((2-hydroxynaphthalen-1-yl)methylene)amino)pentanedioate), has been synthesized and structurally characterized. The DNA binding properties of 1 with calf thymus DNA (CT-DNA) have been investigated by fluorescence and circular dichroism (CD) spectra, results indicate that 1 can bind to CT-DNA via an intercalative mode.

Graphical abstractA novel unexpected oxovanadium(IV) complex with in situ generated lactone Schiff base ligand and 1,10-phenanthroline was synthesized and structurally characterized, its DNA-binding properties with calf thymus DNA were investigated by spectroscopy.Figure optionsDownload full-size imageDownload as PowerPoint slide