A novel paradodecatungstate-B compound decorated by transition metal copper, Na2Cu5(H2O)24(OH)2[H2W12O42]·10H2O: Synthesis, structure and antitumor activities

•A paradodecatungstate-B compound has been synthesized by aqueous solution method.•CuW12 exhibits anti-tumor activity.

A new paradodecatungstate-B compound decorated by transition metal copper, Na2Cu5(H2O)24(OH)2[H2W12O42]·10H2O (1), has been synthesized by convenient aqueous solution method and structurally characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis and TGA. The compound crystallizes in the triclinic P-1 space group with a = 10.7140(8) Å, b = 12.9476(9) Å, c = 13.6696(10) Å, α = 73.56°, β = 75.73°, γ = 67.69°, V = 1661.8(2) Å3 and Z = 1. In compound 1, polyanion of [H2W12O42]10 − acts as a dodecadentate ligand that links copper and sodium cations, forming a remarkable three-dimensional framework. The experiment of antitumor activities in vitro shows that the title compound exhibits remarkable inhibitory actions on human cervical carcinoma HeLa cells, ovarian carcinoma SKOV-3 cells, hepatoma HepG2 cells and neuroblastoma SHY5Y cells.

Graphical abstractCompound 1 consists of [H2W12O42]10 − polyanions linked by copper and sodium cations, forming a remarkable three-dimensional framework. The results of antitumor activities show that 1 has remarkable inhibitory actions on human cervical carcinoma HeLa cells, ovarian carcinoma SKOV-3 cells, hepatoma HepG2 cells and neuroblastoma SHY5Y cells in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide