| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1303601 | Inorganic Chemistry Communications | 2014 | 5 Pages |
•Two novel palladium(II) complexes containing a curcumin analogue are synthesized.•β-diketone ligand coordinates to Pd ion through carbonylic oxygen atoms.•The structure of complex 1 is confirmed by X-ray diffraction.•X-ray powder diffraction for bulk sample is identical with the refined structure.•Complexes 1 and 2 induce apoptosis on human colorectal cancer cells.
Two new palladium complexes with (1E,6E)-1,7-bis(3,4-diethoxyphenyl)-1,6-heptadiene-3,5-dione, 1 and 2, have been synthesized and structurally characterized. Complex 1 has the molecular structure confirmed by X-ray diffraction measurements. Both complexes display a significant antiproliferative activity against human colorectal cancer cells by inducing early and late apoptotic processes in those cells.
Graphical abstractPalladium(II) complexes with curcumin analogues capable to trigger early and late apoptosis in human colorectal cancer cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
