| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1304120 | Inorganic Chemistry Communications | 2012 | 5 Pages |
A new family of tryptophan based mixed-ligand complexes has been synthesized and characterized. DNA (Calf thymus) binding properties of the complexes have been explored by UV–vis, viscosity measurements and cyclic voltammetry. All the experimental evidence suggest that the ancillary ligand 2,2′-bipyridine influences the intercalative binding of these complexes to CT DNA. The DNA cleavage efficiencies of these complexes with pBR322 DNA were investigated by gel electrophoresis. The complexes were found to promote the cleavage of pBR322 DNA from the supercoiled form I to the open circular form II in the presence of an oxidizing agent (H2O2). Microbial property of these complexes as antibacterial agents has been investigated against Gram-negative and Gram-positive bacteria.
Graphical abstractTryptophan based mixed ligand complexes were synthesized and characterized. They can interact with DNA through an intercalative binding mode and exhibit good biocidal efficiency against different organisms.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis of a new family of tryptophan-derived mixed-ligand complexes. ► They were found to act as good intercalators and anti-bacterial agents. ► These chelates exhibit efficient cleavage potential of pBR322 DNA. ► To develop the novel design of new metallonucleases.
