Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1304404 | Inorganic Chemistry Communications | 2009 | 5 Pages |
A series of half-sandwich arene ruthenium complexes containing bidentate thiosemicarbazone ligands have been synthesized and their biological activity investigated. The compounds have the general formula [(6-p-cymene)Ru(R-ATSC)Cl]X (ATSC = 9-anthraldehyde thiosemicarbazone and R = H, CH3 and C6H5). The crystal structure of [(6-p-cymene) Ru(MeATSC)Cl]Cl have been determined and represents the first structurally characterized arene–ruthenium half-sandwich complex with a thiosemicarbazone ligand. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines.
Graphical abstractA series of half-sandwich arene–ruthenium complexes of the type [(η6-p-cymene)Ru(thiosemicarbazone)Cl]+ have been synthesized and their biological activity investigated. The first structurally characterized arene–ruthenium half-sandwich complex with a thiosemicarbazone ligand is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide