Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1305884 | Inorganic Chemistry Communications | 2011 | 5 Pages |
The preparation of two M(CO)3 complexes (M = Re and 99mTc) from a novel pyridyltriazole-based ligand 2 bearing the bioactive (2-methoxyphenyl)piperazine pharmacophore are described. Spectral data, X-ray structure and DFT calculations of the rhenium(I) complex as well as the 99mTc-labelling of 2 are reported. Both complexes were neutral and iso-structural. Moreover, the 99mTc-complex presented a suitable lipophilic character for its use as a CNS imaging agent.
Graphical AbstractThe preparation of two M(CO)3 complexes (M = Re and 99mTc) from a novel pyridyltriazole-based ligand 2 bearing the bioactive (2-methoxyphenyl)piperazine pharmacophore are described. Spectral data, X-ray structure and DFT calculations of the rhenium(I) complex as well as the 99mTc-labelling of 2 are reported. Both complexes were neutral and iso-structural. Moreover, the 99mTc-complex presented a suitable lipophilic character for its use as a CNS imaging agent.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights► A novel pyridyltriazole-based ligand bearing a bioactive moiety is reported. ► the corresponding Re- and Tc-complexes were neutral and iso-structural. ► 99mTc-complex presented a suitable lipophilicity for its use as a CNS imaging agent.