| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358570 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
From an easily available partially protected formal derivative of 1-deoxymannojirimycin, by hydroxymethyl chain-branching and further elaboration, lipophilic analogs of the powerful β-d-galactosidase inhibitor 4-epi-isofagomine have become available. New compounds exhibit improved inhibitory activities comparable to benchmark compound NOEV (N-octyl-epi-valienamine) and may serve as leads towards improved and more selective pharmacological chaperones for GM1-gangliosidosis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martin Thonhofer, Patrick Weber, Andres Gonzalez Santana, Roland Fischer, Bettina M. Pabst, Eduard Paschke, Michael Schalli, Arnold E. Stütz, Marion Tschernutter, Werner Windischhofer, Stephen G. Withers,