| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358582 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
Beginning with a diaminotriazine screening hit, several series of novel, tricyclic gamma-secretase modulators (GSMs) were designed. The SAR of several related series of GSMs is presented, and the in vivo profile of a lead molecule from the series is described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianliang Shi, Dmitry Zuev, Li Xu, Kimberley A. Lentz, James E. Grace, Jeremy H. Toyn, Richard E. Olson, John E. Macor, Lorin A. Thompson,