| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358720 | Bioorganic & Medicinal Chemistry Letters | 2015 | 7 Pages |
Abstract
Spectroscopic studies of ether rifamycins (1–9) have shown that all these compounds tend to be zwitterions with different localizations of intramolecularly transferred proton, which influences their solubility and log P values. According to ESI MS studies, rifamycins 3 and 4 form complexes with Li+ or Na+, while the other ones (7–9) coordinate small organic molecules, which can be further replaced by Na+ cation. Biological assays revealed that the use of 7–9 in the form of complexes with small organic molecules improves their antibacterial potency as a result of changed: log P, solubility and binding mode with bacterial RNA polymerases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Piotr Przybylski, Krystian Pyta, Dominika Czerwonka, Marcelina M. Kubicka, Marzena Gajecka,