| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358728 | Bioorganic & Medicinal Chemistry Letters | 2015 | 6 Pages |
Abstract
Chemical evolution of mibefradil resulted in the identification of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers. A SAR study, in vitro and in vivo DMPK properties as well as the in vivo antihypertensive effect in rats are presented.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dorte Renneberg, Francis Hubler, Markus Rey, Patrick Hess, Stephane Delahaye, John Gatfield, Marc Iglarz, Kurt Hilpert,