| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358887 | Bioorganic & Medicinal Chemistry Letters | 2015 | 7 Pages |
Abstract
Novel, mesalazine, metronidazole conjugates 6a–e with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates exhibit comparable anti-inflammatory activity with parent drugs and (b) the potent bis-conjugates show no visible stomach lesions. 3D-pharmacophore and 2D-QSAR modeling support the observed bio-properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Roman N. Naumov, Siva S. Panda, Adel S. Girgis, Riham F. George, Michel Farhat, Alan R. Katritzky,