| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358888 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
Two high-throughput screening hits were investigated for SAR against human factor IXa. Both hits feature a benzamide linked to a [6-5]-heteroaryl via an alkyl amine. In the case where this system is a benzimidazolyl-ethyl amine the binding potency for the hit was improved >500-fold, from 9 μM to 0.016 μM. For the other hit, which contains a tetrahydropyrido-indazole amine, potency was improved 20-fold, from 2 μM to 0.09 μM. X-ray crystal structures were obtained for an example of each class which improved understanding of the binding, and will enable further drug discovery efforts.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dann L. Parker Jr., Shawn Walsh, Bing Li, Esther Kim, Aurash Sharipour, Cameron Smith, Yi-Heng Chen, Richard Berger, Bart Harper, Ting Zhang, Min Park, Min Shu, Jane Wu, Jiayi Xu, Sunita Dewnani, Edward C. Sherer, Alan Hruza, Paul Reichert,