| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358900 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
Recently we reported benzohydroxamic acids (BHAs) as potent and selective inhibitors of hepatitis C virus (HCV) replicon propagation. In this work 12 pyridine hydroxamic acids (PHAs) were synthesized and tested in full-genome replicon assay. It was found that PHAs possessed very similar anti-HCV properties compared to BHAs. Both classes of hydroxamic acids caused hyperacetylation of α-tubulin pointing to inhibition of histone deacetylase 6 (HDAC6) as part of their antiviral activity. The tested compounds did not inhibit the growth of poliovirus, displaying high selectivity against HCV.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maxim V. Kozlov, Alla A. Kleymenova, Lyudmila I. Romanova, Konstantin A. Konduktorov, Kamila A. Kamarova, Olga A. Smirnova, Vladimir S. Prassolov, Sergey N. Kochetkov,