Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1358902 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
1H-1,2,3-Triazolylbenzohydrazides (6a–h and 11a–l) were synthesized from 2-chloronicotinaldehydes and evaluated for anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv strain (ATCC-27294). Seven compounds 6b, 6e,f, 11d, 11h, 11j and 11l displayed potent anti-mycobacterial activity (MIC 2.8–6.2 μM). Potent anti-mycobacterial compounds were chosen for cytotoxicity studies by MTT protein assay against normal cell lines (PBMC and Raw 264.7) and shown low cytotoxicity. This is the first Letter assigning anti-mycobacterial activity, cytotoxicity and structure activity relationship for 1H-1,2,3-triazolylbenzohydrazides.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Pathi Suman, Cherupally Dayakar, Kommera Rajkumar, Bomma Yashwanth, Perumal Yogeeswari, Dharmarajan Sriram, Janapala Venkateswara Rao, Bhimapaka China Raju,