Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1358908 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
There are many reports for andrographolide modification regarding antitumor effects. Transformation of the five-membered lactone ring to furan aromatic ring still results in compounds with good cytotoxicity. To determine further the importance of the five-membered lactone ring and to obtain better lead compounds, we transformed the five-membered lactone ring in andrographolide. New types of ent-labdane diterpene derivatives were made, whose cytotoxic activities were measured in vitro. Preliminary SAR was summarized and two compounds, 7 and 26, with good cytotoxic activity were obtained, which have the potential to be developed into new antitumor drugs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yan Luo, Ke Wang, Meng-han Zhang, Da-yong Zhang, Yang-chang Wu, Xiao-ming Wu, Wei-yi Hua,