Article ID Journal Published Year Pages File Type
1359355 Bioorganic & Medicinal Chemistry Letters 2014 7 Pages PDF
Abstract

A total of 54 natural origin compounds were evaluated for their activity in inhibiting the proliferation of glioma cells. Results showed that four Aesculus polyhydroxylated triterpenoid saponins (3–6), six Gleditsia triterpenoid saponins (7–12), and five phenolic compounds (43–46, 51) had dose-dependent activity suppressing the proliferation of both C6 and U251 cells. Structure–activity relationship analysis suggested that the acetyl group at C-28 for the Aesculus saponins and the monoterpenic acid moiety for the Gleditsia saponins could be critical for the activity of these active compounds. Aesculioside H (4), gleditsioside A (7), and feuric acid 3,4-dihydroxyphenethyl ester (FADPE, 46) were the three most active compounds from the different types of the active compounds and induced apoptosis and necrosis in glioma cells.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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