| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1359357 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Microwave-assisted synthesis of 23 α-cyano bis(indolyl)chalcones (6a–w) and their in vitro anticancer activity against three human cancer cell lines have been discussed. Among the synthesized chalcones, compound 6n was found to be the most potent and selective against A549 lung cancer cell line (IC50 = 0.8 μM). In a preliminary mechanism of action studies some α-cyano bis(indolyl)chalcones were found to enhance tubulin polymerization suggesting these compounds could act as microtubule stabilizing agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dalip Kumar, N. Maruthi Kumar, Mukund P. Tantak, Maiko Ogura, Eriko Kusaka, Takeo Ito,