Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1359363 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A number of cytotoxic conjugated unsaturated ketones were screened for their membrane permeability characteristics using Caco-2 and MDCK cells with the view of finding promising leads for in vivo evaluations. 3b–e and 4a–b demonstrated high permeability characteristics. In particular, 4a emerged as a promising lead which showed excellent apparent permeability (Papp: 54.70) and efflux ratio (ER: 0.15) values. In general, the relative apparent permeabilities of these enones are similar in both bioassays.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravi S.P. Singh, Deborah Michel, Umashankar Das, Jonathan R. Dimmock, Jane Alcorn,