Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1359364 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A small molecule containing a rhodium(II) tetracarboxylate fragment is shown to be a potent inhibitor of the prolyl isomerase FKBP12. The use of small molecules conjugates of rhodium(II) is presented as a general strategy for developing new protein inhibitors based on distinct structural and sequence features of the enzyme active site.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jane M. Coughlin, Rituparna Kundu, Julian C. Cooper, Zachary T. Ball,