Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1359373 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Quaternary ammonium salts substituted with a long alkyl chain exemplify a trustworthy group of medicinal compounds frequently employed as antifungal and antibacterial agents. A great asset of these surfactants underlying their widespread use is low local and system toxicity in humans. In this Letter, a series of novel quaternary 6-hydroxyquinolinium salts with varying length of N-alkyl chain (from C10 to C18) was synthesized and tested for in vitro activity against pathogenic bacterial and fungal strains. 6-Hydroxyquinolinium salt with C12 alkyl chain seems to be very interesting candidate due to a high antimicrobial efficacy and cytotoxic safety.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David Malinak, Rafael Dolezal, Jan Marek, Sarka Salajkova, Ondrej Soukup, Marcela Vejsova, Jan Korabecny, Jan Honegr, Marek Penhaker, Kamil Musilek, Kamil Kuca,