| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1359545 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
The dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporter releasing activity and serotonin-2A (5-HT2A) receptor agonist activity of a series of substituted tryptamines are reported. Three compounds, 7b, (+)-7d and 7f, were found to be potent dual DA/5-HT releasers and were >10-fold less potent as NE releasers. Additionally, these compounds had different activity profiles at the 5-HT2A receptor. The unique combination of dual DA/5-HT releasing activity and 5-HT2A receptor activity suggests that these compounds could represent a new class of neurotransmitter releasers with therapeutic potential.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bruce E. Blough, Antonio Landavazo, John S. Partilla, Ann M. Decker, Kevin M. Page, Michael H. Baumann, Richard B. Rothman,