Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1359947 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
We describe a medicinal chemistry approach to generate a series of 2-(1H-pyrazol-1-yl)thiazole compounds that act as selective EP1 receptor antagonists. The obtained results suggest that compound 12 provides the best EP1 receptor antagonist activity and demonstrates good oral pharmacokinetics.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masakazu Atobe, Kenji Naganuma, Masashi Kawanishi, Akifumi Morimoto, Ken-ichi Kasahara, Shigeki Ohashi, Hiroko Suzuki, Takahiko Hayashi, Shiro Miyoshi,