Article ID Journal Published Year Pages File Type
1359947 Bioorganic & Medicinal Chemistry Letters 2013 4 Pages PDF
Abstract

We describe a medicinal chemistry approach to generate a series of 2-(1H-pyrazol-1-yl)thiazole compounds that act as selective EP1 receptor antagonists. The obtained results suggest that compound 12 provides the best EP1 receptor antagonist activity and demonstrates good oral pharmacokinetics.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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