| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1359958 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A new series of 2-(benzyloxy)benzamides are presented that are potent functional antagonists of TRPM8 and possess improved LipE and LE compared to the original lead. They were discovered through a series of compound libraries and we present a powerful visualization method for the chemical space explored with each library. Remarkably this new series originated from the highest risk design strategy where compounds were synthesised with the least degree of similarity to the lead structure.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alan Brown, David Ellis, David A. Favor, Tony Kirkup, Wolfgang Klute, Malcolm MacKenny, Gordon McMurray, Adam Stennett,