| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1359966 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Overcoming drug resistance with remarkable cytotoxic activity by anthracene-9,10-dione derivatives would offer a potential therapeutic strategy. In this study, we report the synthesis and the cytotoxicity of a novel set of anthraquninones. (4-(4-Aminobenzylamino)-9,10-dioxo-9,10-dihydroanthracen-1-yl-4-methylbenzenesulfonate) (3) has excellent in vitro cytotoxicity against doxorubicin-resistant cancer cell line (IC50 = 0.8 μM), 20-fold higher than doxorubicin. The cytotoxic effect via G2/M arrest does not appear to be ROS.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Supranee Sangthong, Helen Ha, Thapong Teerawattananon, Nattaya Ngamrojanavanich, Nouri Neamati, Nongnuj Muangsin,