| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1359971 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Concise syntheses of two Leucetta-derived naphthimidazole alkaloids, kealiiquinone and 2-deoxy-2-aminokealiiquinone, are described based on a biosynthetic-guided hypothesis. Advanced intermediates containing the full naphthimidazole framework are constructed through Friedel–Crafts chemistry followed by oxidation of the electron rich C-ring with hydrogen peroxide. The cytotoxicity of these alkaloids in a breast cancer cell line along with several closely related marine-derived natural products kealiinines A–C and analogs are reported.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jayanta Das, Arunoday Bhan, Subhrangsu S. Mandal, Carl J. Lovely,