| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1359972 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including diabetic neuropathy.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong-Jin Wu, Charles M. Conway, Li-Qiang Sun, Frederic Machet, Jie Chen, Ping Chen, Huan He, Clotilde Bourin, Vincenzo Calandra, Joseph L. Polino, Carl D. Davis, Karen Heman, Valentin K. Gribkoff, Christopher G. Boissard, Ronald J. Knox,