Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1361254 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Thiourea derivatives (6a–e) were developed and screened for antitumor and anti-inflammatory activity. Most of the compounds exhibited growth inhibitory effects comparable to 5-fluorouracil in vitro against mammary (MCF-7 and MDA-MB 231) as well as colon (HT-29) carcinoma cells. They also showed stronger anti-inflammatory activity than ibuprofen in vivo in the xylene-induced ear swelling assay in mice.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wukun Liu, Jinpei Zhou, Tong Zhang, Haiyang Zhu, Hai Qian, Huibin Zhang, Wenlong Huang, Ronald Gust,