| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361256 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H37Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent in the series against MTB H37Rv with MIC value of 0.125 μg/mL.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rama Krishna Yadlapalli, O.P. Chourasia, Kiranmayi Vemuri, Manjula Sritharan, Ramu Sridhar Perali,