Article ID Journal Published Year Pages File Type
1361271 Bioorganic & Medicinal Chemistry Letters 2012 4 Pages PDF
Abstract

A series of 1,2,4-triazole derivatives containing thiosemicarbazone linkage was synthesized and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. All the compounds were capable of inhibiting the growth of E. histolytica out of which four compounds (IC50 = 0.28–1.38 μM) were found to have better efficacy than the standard drug Metronidazole (IC50 = 1.8 μM). Cytotoxicity of the active compounds was assessed by MTT assay using human breast cancer MCF-7 cell line, which revealed that all the compounds were low cytotoxic in the concentration range of 2.5–250 μM.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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