Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1361271 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of 1,2,4-triazole derivatives containing thiosemicarbazone linkage was synthesized and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. All the compounds were capable of inhibiting the growth of E. histolytica out of which four compounds (IC50 = 0.28–1.38 μM) were found to have better efficacy than the standard drug Metronidazole (IC50 = 1.8 μM). Cytotoxicity of the active compounds was assessed by MTT assay using human breast cancer MCF-7 cell line, which revealed that all the compounds were low cytotoxic in the concentration range of 2.5–250 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shadab Miyan Siddiqui, Attar Salahuddin, Amir Azam,