| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361275 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of aminopyrazines as inhibitors of Syk kinase activity and showing inhibition of LAD2 cells degranulation is described. Optimization of the carboxamide motif with aminomethylpiperidines provided high potency inhibiting Syk but low cellular activity. Amides of cis and trans adamantanol showed good inhibitory activity against Syk as well as remarkable activity in LAD2 cells degranulation assay.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pilar Forns, Cristina Esteve, Lorena Taboada, Juan Antonio Alonso, Adelina Orellana, Mónica Maldonado, Cristina Carreño, Isabel Ramis, Manel López, Montserrat Miralpeix, Bernat Vidal,