| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361277 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Novel indole-propionic acid derivatives were developed as sphingosine-1-phosphate (S1P) receptor agonists through a systematic SAR study. The optimized and S1P3 selective S1P1 agonist 9f induced peripheral blood lymphocyte reduction in vivo and has an excellent efficacy in mouse experimental autoimmune encephalomyelitis (EAE).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qinghua Meng, Baowei Zhao, Qiongfeng Xu, Xuesong Xu, Guanghui Deng, Chengyong Li, Linbo Luan, Feng Ren, Hailong Wang, Heng Xu, Yan Xu, Haibo Zhang, Jia-Ning Xiang, John D. Elliott, Taylor B. Guo, Yonggang Zhao, Wei Zhang, Hongtao Lu, Xichen Lin,