| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361315 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Timothy E. Long, Xiao Lu, Melina Galizzi, Roberto Docampo, Jiri Gut, Philip J. Rosenthal,