Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1361317 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Facile synthesis of natural α-noscapine analogue, 9-amino-α-noscapine, a potent inhibitor of tubulin polymerization for cancer therapy, is achieved via copper(I) iodide mediated in situ aromatic azidation and reduction of 9-bromo-α-noscapine (obtained by bromination of natural α-noscapine) with NaN3 in DMSO at 130 °C in the presence of l-proline as an amino acid promoter. The protocol developed here avoided isolation of 9-azido-α-noscapine and did not cleave the sensitive C–C bond between two heterocyclic phthalide and isoquinoline units.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Naresh K. Manchukonda, Balasubramanian Sridhar, Pradeep K. Naik, Harish C. Joshi, Srinivas Kantevari,