New bisabolane sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from the sponge Xestospongia testudinaria

Three new phenolic bisabolane sesquiterpenoid dimers, disydonols A–C (1–3), and one known compound (S)-(+)-sydonol (4) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Their structures were elucidated on the basis of comprehensive spectral analysis including 1D and 2D NMR spectra and HR-ESI-MS. These compounds were evaluated for cytotoxic activity against HepG-2 and Caski human tumour cell lines. Among them, compounds 1 and 3 exhibited cytotoxicity against the two cell lines.

Graphical abstractThree new phenolic bisabolane sesquiterpenoid dimers, disydonols A–C (1–3), and one known compound (S)-(+)-sydonol (4) were isolated from Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria. Compounds 1 and 3 displayed cytotoxicity toward HepG-2 and Caski human tumour cell lines. The preliminary bioactivity assay indicated that mesomeric effect might decrease cytotoxic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide