| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361485 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of pyrazoloquinolines, possessing (hetero)arylhydroxymethyl substituents at the quinoline C-4 position were evaluated as PDE10A inhibitors. Among these, methylpyrimidyl analogue 15 was identified as having good rodent and monkey exposure, and a MED of 10 mg/kg in an in vivo model.
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Related Topics
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Organic Chemistry
Authors
William T. McElroy, Zheng Tan, Kallol Basu, Shu-Wei Yang, Jennifer Smotryski, Ginny D. Ho, Deen Tulshian, William J. Greenlee, Deborra Mullins, Mario Guzzi, Xiaoping Zhang, Carina Bleickardt, Robert Hodgson,