| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361494 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Monoamine oxidase B (MAO-B) inhibitors are used to treat Parkinson’s disease. In this study, we searched for novel MAO-B inhibitors using a scaffold hopping approach based on our experience with the thiazolidinedione (TZD) class of compounds as MAO-B inhibitors. Several novel compounds were identified, with potencies in the low nanomolar and low micromolar range. We also found that derivatives of the natural product sulfuretin are potent MAO-A and MAO-B inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Werner J. Geldenhuys, Max O. Funk, Cornelis J. Van der Schyf, Richard T. Carroll,