| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361495 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
We report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases. Several of the compounds display nanomolar binding affinity for CCR2. The in vitro structure–activity relationships of 4 are described, and are also reconciled with those from the related 2-phenylsulfonylmethyl series.
Graphical abstractWe report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases. Several of the compounds display nanomolar binding affinity for CCR2. The in vitro structure–activity relationships of 4 are described, and are also reconciled with those from the related 2-phenylsulfonylmethyl series.Figure optionsDownload full-size imageDownload as PowerPoint slide
