Article ID Journal Published Year Pages File Type
1361503 Bioorganic & Medicinal Chemistry Letters 2012 6 Pages PDF
Abstract

In this Letter we describe the optimization of an aminopurine lead (1) with modest potency and poor overall kinase selectivity which led to the identification of a series of potent, selective JNK inhibitors. Improvement in kinase selectivity was enabled by introduction of an aliphatic side chain at the C-2 position. CC-359 (2) was selected as a potential clinical candidate for diseases manifested by ischemia reperfusion injury.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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