| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361505 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5′-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vemula Praveen Kumar, R. Gajendra Reddy, Duc Duy Vo, Sumana Chakravarty, Srivari Chandrasekhar, René Grée,