| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361715 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A novel reaction of indole with aryldiazonium salts leading to the formation of 2-aryl-3-(arylazo)indoles was discovered. The products were found to possess potent anti-MRSA and anti-LLVRE activities. The SAR studies indicate that the potentially metabolically labile azo functionality can be replaced with ether oxygen and thioether sulfur atoms without any loss of activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seth Daly, Kathryn Hayden, Indranil Malik, Nikki Porch, Hong Tang, Snezna Rogelj, Liliya V. Frolova, Katrina Lepthien, Alexander Kornienko, Igor V. Magedov,