Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1361731 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A short practical synthesis of a new natural product based scaffold (6), based on antitrypanosomal and antimalarial compounds isolated from different Plakortis species is described. The scaffold contains a peroxide unit that is surprisingly stable to chemical manipulation elsewhere in the molecule, enabling it to be elaborated into a small library of derivatives. It is stable to ozonolysis, reductive work-up with dimethylsulfide and the Wittig reaction with stabilized phosphorus ylides. The scaffold along with its Wittig analogues has displayed low to sub-micro molar (0.2–3.3 μM) antitrypanosomal activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Harish Holla, Mehdi Labaied, Ngoc Pham, Ian D. Jenkins, Kenneth Stuart, Ronald J. Quinn,