| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361739 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
SAR of a novel series of pyridine-derived γ-secretase modulators is described. Compound 5 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain (or increase) the levels of total Aβ. Furthermore, representative compounds 1 and 5 demonstrated in vivo efficacy to lower Aβ42 in the brain without altering Notch processing in the peripheral.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Zehong Wan, Adrian Hall, Yingxia Sang, Jia-Ning Xiang, Eric Yang, Beverley Smith, David C. Harrison, Guang Yang, Haihua Yu, Helen S. Price, Jian Wang, Julie Hawkins, Lit-Fui Lau, Matthew R. Johnson, Tina Li, Wei Zhao, William L. Mitchell, Xiaobo Su,