Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1361746 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Solid phase synthesis of the cyclic depsipeptides of callipeltin B analogues and evaluation of cytotoxicity of synthetic peptides are described. We attempted to synthesize cyclic depsipeptides via the esterification or the amide bond formation for cyclization steps. In the assay of synthetic peptides, the linear peptide (10) exhibited modest cytotoxicity against HeLa cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mari Kikuchi, Yoshihisa Watanabe, Masaki Tanaka, Kenichi Akaji, Hiroyuki Konno,