| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1361752 | Bioorganic & Medicinal Chemistry Letters | 2011 | 9 Pages |
Abstract
A series of 6-aryl-3-pyrrolidinylpyridine analogs was explored as structurally novel negative allosteric modulators of the mGlu5 receptor lacking an alkyne or oxadiazole moiety. Compounds in this series were characterized by tractable SAR, good in vitro potencies and brain penetration in rodents.
Graphical abstractA series of 6-aryl-3-pyrrolidinylpyridine analogs was explored as structurally novel negative allosteric modulators of the mGlu5 receptor lacking an alkyne or oxadiazole moiety. Compounds in this series were characterized by tractable SAR, good in vitro potencies and brain penetration in rodents.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jesse M. Weiss, Hermogenes N. Jimenez, Guiying Li, Myriam April, Michelle A. Uberti, Maria D. Bacolod, Robb M. Brodbeck, Darío Doller,